Failure of methapyrilene to induce tumors in hamsters or guinea pigs

• Published in: Journal of toxicology and environmental health Vol. 12; no. 4-6; p. 653
• Main Authors: Lijinsky, W, Knutsen, G, Reuber, M D
• Format: Journal Article
• Language: English
• Published: United States 01.10.1983
• Subjects: Aminopyridines - toxicity; Animals; Cricetinae; Female; Guinea Pigs; Male; Mesocricetus; Methapyrilene - toxicity; Neoplasms, Experimental - chemically induced; Species Specificity
• DOI: 10.1080/15287398309530457
• ISSN: 0098-4108

In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage twice a week for 78 wk with a 200-mg/kg body weight dose of methapyrilene hydrochloride dissolved in water, a total dose of approximately 30 g/kg body weight. By the end of the treatment more than half of the animals were still alive: survivors were killed at 132 wk. A group of 20 male Syrian golden hamsters was treated twice a week by gavage with 15 mg methapyrilene hydrochloride for 58 wk, a total dose of approximately 15 g/kg body weight. Thirteen animals survived an acute convulsant effect, and the last 4 were killed at wk 61. There was no significant incidence of any tumor that could be attributed to the treatment in either guinea pigs or hamsters.