Failure of methapyrilene to induce tumors in hamsters or guinea pigs

In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage twice a week for 78 wk with a 200-mg/kg body weight dose of methapyrilene hydrochloride dissolved in water, a total dose of approximately 30 g/kg body weight. By the end of the treatment more than half of...

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Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 12; no. 4-6; p. 653
Main Authors Lijinsky, W, Knutsen, G, Reuber, M D
Format Journal Article
LanguageEnglish
Published United States 01.10.1983
Subjects
Aminopyridines - toxicity
Animals
Cricetinae
Female
Guinea Pigs
Male
Mesocricetus
Methapyrilene - toxicity
Neoplasms, Experimental - chemically induced
Species Specificity
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Summary:In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage twice a week for 78 wk with a 200-mg/kg body weight dose of methapyrilene hydrochloride dissolved in water, a total dose of approximately 30 g/kg body weight. By the end of the treatment more than half of the animals were still alive: survivors were killed at 132 wk. A group of 20 male Syrian golden hamsters was treated twice a week by gavage with 15 mg methapyrilene hydrochloride for 58 wk, a total dose of approximately 15 g/kg body weight. Thirteen animals survived an acute convulsant effect, and the last 4 were killed at wk 61. There was no significant incidence of any tumor that could be attributed to the treatment in either guinea pigs or hamsters.
ISSN:0098-4108
DOI:10.1080/15287398309530457