Molecular Mechanism of Brain Impairment Caused by Drinking-Acquired Fluorosis and Selenium Intervention

• Published in: Environmental toxicology and pharmacology Vol. 43; pp. 134 - 139
• Main Authors: Zheng, Xiangren, Sun, Yan, Ke, Lulu, Ouyang, Wei, Zhang, Zigui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2016
• Subjects: Animals; Apoptosis; Brain - drug effects; Brain - physiology; Brain damage; Caspase 3 - genetics; Caspase 9 - genetics; Drinking Water; Emergency; Fluorides - toxicity; Fluorosis; Fluorosis, Dental - metabolism; Fluorosis, Dental - prevention & control; Hippocampus; Male; Neuroprotective Agents - pharmacology; Protective Agents - pharmacology; Rats; RNA, Messenger - metabolism; Selenium; Selenium - pharmacology; Water Pollutants, Chemical - toxicity; Brain damage; Fluorosis; Selenium; Hippocampus; Apoptosis

Highlights • Verify the mitochondrial apoptosis pathway leads to fluorosis-induced brain damage. • Put forward the Cytc molecules are possibly the key target molecules in apoptosis. • Verify selenium has an intervention effect on fluorosis-induced apoptosis.