Molecular Mechanism of Brain Impairment Caused by Drinking-Acquired Fluorosis and Selenium Intervention

Highlights • Verify the mitochondrial apoptosis pathway leads to fluorosis-induced brain damage. • Put forward the Cytc molecules are possibly the key target molecules in apoptosis. • Verify selenium has an intervention effect on fluorosis-induced apoptosis.

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Bibliographic Details
Published inEnvironmental toxicology and pharmacology Vol. 43; pp. 134 - 139
Main Authors Zheng, Xiangren, Sun, Yan, Ke, Lulu, Ouyang, Wei, Zhang, Zigui
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2016
Subjects
Animals
Apoptosis
Brain - drug effects
Brain - physiology
Brain damage
Caspase 3 - genetics
Caspase 9 - genetics
Drinking Water
Emergency
Fluorides - toxicity
Fluorosis
Fluorosis, Dental - metabolism
Fluorosis, Dental - prevention & control
Hippocampus
Male
Neuroprotective Agents - pharmacology
Protective Agents - pharmacology
Rats
RNA, Messenger - metabolism
Selenium
Selenium - pharmacology
Water Pollutants, Chemical - toxicity
Brain damage
Fluorosis
Selenium
Hippocampus
Apoptosis
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Summary:Highlights • Verify the mitochondrial apoptosis pathway leads to fluorosis-induced brain damage. • Put forward the Cytc molecules are possibly the key target molecules in apoptosis. • Verify selenium has an intervention effect on fluorosis-induced apoptosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.02.017