Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

• Published in: Life sciences (1973) Vol. 65; no. 18; pp. 1883 - 1892
• Main Authors: Butterfield, D.Allan, Howard, Beverly, Yatin, Servet, Koppal, Tanuja, Drake, Jennifer, Hensley, Kenneth, Aksenov, Michael, Aksenova, Marina, Subramaniam, Ram, Varadarajan, Sridhar, Harris-White, Marni E., Pedigo, Norman W., Carney, John M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.1999
• Subjects: aging; Aging - metabolism; Aging - physiology; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Brain - metabolism; free radicals; Free Radicals - metabolism; Humans; hydroxynonenal; lipid peroxidation; Oxidative Stress - physiology; protein oxidation; Reactive Oxygen Species - metabolism; β-amyloid; free radicals; hydroxynonenal; protein oxidation; aging; lipid peroxidation; Alzheimer's disease; β-amyloid
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/S0024-3205(99)00442-7

Age-associated neurodegenerative disorders are becoming more prevalent as the mean age of the population increases in the United States over the next few decades. Both normal brain aging and Alzheimer's disease (AD) are associated with oxidative stress. Our laboratory has used a wide variety of physical and biochemical methods to investigate free radical oxidative stress in several models of aging and AD. β-amyloid (Aβ), the peptide that constitutes the central core of senile plaques in AD brain, is associated with free radical oxidative stress and is toxic to neurons. This review summarizes some of our studies in aging and Aβ-associated free radical oxidative stress and on the modulating effects of free radical scavengers on neocortical synaptosomal membrane damage found in aging and Aβ-treated systems.