Serotonergic neurons in the nucleus raphé obscurus are not involved in the ventilatory and thermoregulatory responses to hypoxia in adult rats

• Published in: Respiratory physiology & neurobiology Vol. 187; no. 2; pp. 139 - 148
• Main Authors: da Silva, Glauber S.F, Giusti, Humberto, Castro, Olagide W, Garcia-Cairasco, Norberto, Gargaglioni, Luciane H, Branco, Luiz G.S, Glass, Mogens L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2013
• Subjects: Animals; Antibodies - pharmacology; Blood Gas Analysis; Body temperature; Body Temperature - drug effects; Body Temperature - physiology; Body Temperature Regulation - drug effects; Body Temperature Regulation - physiology; Caudal medullary raphé; Cell Count; Disease Models, Animal; Excitatory Amino Acid Agonists - toxicity; Hypoxia; Hypoxia - pathology; Hypoxia - physiopathology; Ibotenic Acid - toxicity; Male; Medical Education; Microinjections; Plethysmography, Whole Body; Pulmonary ventilation; Pulmonary Ventilation - drug effects; Pulmonary Ventilation - physiology; Pulmonary/Respiratory; Raphe Nuclei - pathology; Rats; Rats, Wistar; RNA-Binding Proteins - immunology; Serotonergic Neurons - physiology; Serotonin; Serotonin - metabolism; Time Factors; Hypoxia; Pulmonary ventilation; Serotonin; Body temperature; Caudal medullary raphé
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2013.04.008

Highlights • Medullary raphe (MR) is an important part of central respiratory network. • Literature describes difference between rostral and caudal MR on respiratory control. • We studied the role of nucleus raphe obscurus in the ventilatory responses to hypoxia. • Thermal response to hypoxia was also assessed. • Chemical lesion of caudal MR did not affect these responses to hypoxia.