The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

• Published in: Environmental toxicology and pharmacology Vol. 38; no. 3; pp. 774 - 782
• Main Authors: Bacanlı, Merve, Aydın, Sevtap, Taner, Gökçe, Göktaş, Hatice Gül, Şahin, Tolga, Başaran, A. Ahmet, Başaran, Nurşen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2014
• Subjects: Alkaline single cell electrophoresis; Animals; Antioxidants - administration & dosage; Antioxidants - pharmacology; Coumaric Acids - administration & dosage; Coumaric Acids - pharmacology; DNA damage; DNA Damage - drug effects; Emergency; Ferulic acid; Gene Expression Regulation - drug effects; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Kidney - metabolism; Liver - metabolism; Lymphocytes - metabolism; Malondialdehyde - metabolism; Oxidative Stress - drug effects; Rats; Rats, Wistar; Sepsis; Sepsis - metabolism; Sepsis - pathology; Superoxide Dismutase - metabolism; Sepsis; DNA damage; Alkaline single cell electrophoresis; Ferulic acid
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2014.08.018

Highlights • The effects of ferulic acid (FA) on sepsis-induced oxidative damage in thelymphocytes, liver and kidney cells of Wistar albino rats were investigated. • The DNA damage was found to be significantly higher in the sepsis-induced rats ( p < 0.05). • The Comet parameters were significantly decreased in the FA-treated sepsis-induced group when compared with the sepsis-induced group. • FA treatment also decreased the malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities and increased the glutathione (GSH) levels and superoxide dismutase (SOD) activities in the sepsis-induced rats.