The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
Highlights • The effects of ferulic acid (FA) on sepsis-induced oxidative damage in thelymphocytes, liver and kidney cells of Wistar albino rats were investigated. • The DNA damage was found to be significantly higher in the sepsis-induced rats ( p < 0.05). • The Comet parameters were significant...
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Published in | Environmental toxicology and pharmacology Vol. 38; no. 3; pp. 774 - 782 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.11.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • The effects of ferulic acid (FA) on sepsis-induced oxidative damage in thelymphocytes, liver and kidney cells of Wistar albino rats were investigated. • The DNA damage was found to be significantly higher in the sepsis-induced rats ( p < 0.05). • The Comet parameters were significantly decreased in the FA-treated sepsis-induced group when compared with the sepsis-induced group. • FA treatment also decreased the malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities and increased the glutathione (GSH) levels and superoxide dismutase (SOD) activities in the sepsis-induced rats. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1382-6689 1872-7077 |
DOI: | 10.1016/j.etap.2014.08.018 |