Cytonemes as specialized signaling filopodia
Development creates a vast array of forms and patterns with elegant economy, using a small vocabulary of pattern-generating proteins such as BMPs, FGFs and Hh in similar ways in many different contexts. Despite much theoretical and experimental work, the signaling mechanisms that disperse these morp...
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| Published in | Development (Cambridge) Vol. 141; no. 4; pp. 729 - 736 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Company of Biologists
15.02.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Development creates a vast array of forms and patterns with elegant economy, using a small vocabulary of pattern-generating proteins such as BMPs, FGFs and Hh in similar ways in many different contexts. Despite much theoretical and experimental work, the signaling mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests that cytoneme-mediated signaling is a dispersal mechanism that delivers signaling proteins directly at sites of cell-cell contact. |
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| AbstractList | Development creates a vast array of forms and patterns with elegant economy, using a small vocabulary of pattern-generating proteins such as BMPs, FGFs and Hh in similar ways in many different contexts. Despite much theoretical and experimental work, the signaling mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests that cytoneme-mediated signaling is a dispersal mechanism that delivers signaling proteins directly at sites of cell-cell contact. |
| Author | Kornberg, Thomas B Roy, Sougata |
| Author_xml | – sequence: 1 givenname: Thomas B surname: Kornberg fullname: Kornberg, Thomas B organization: Cardiovascular Research Institute, University of California, San Francisco, CA 94156, USA – sequence: 2 givenname: Sougata surname: Roy fullname: Roy, Sougata |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24496611$$D View this record in MEDLINE/PubMed |
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| Keywords | Gradient Morphogen Cytoneme transfer Filopodia Drosophila Cytoneme plasticity |
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| Title | Cytonemes as specialized signaling filopodia |
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