Developmental origin and lineage plasticity of endogenous cardiac stem cells

Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their lineage origins and in vivo functions remain largely unexplored. This Review summarizes what is known about different populations of embryonic and...

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Published inDevelopment (Cambridge) Vol. 143; no. 8; pp. 1242 - 1258
Main Authors Santini, Maria Paola, Forte, Elvira, Harvey, Richard P, Kovacic, Jason C
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 15.04.2016
Subjects
Adult Stem Cells
Animals
Cell Differentiation
Cell Lineage
Embryonic Stem Cells
Humans
Myocardium - cytology
Review
Stem Cells - cytology
Adult mammalian heart
Cardiac stem cells
Regeneration
Embryonic precursor cells
Cardiovascular cells
Heart organogenesis
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Summary:Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their lineage origins and in vivo functions remain largely unexplored. This Review summarizes what is known about different populations of embryonic and adult cardiac stem cells, including KIT(+), PDGFRα(+), ISL1(+)and SCA1(+)cells, side population cells, cardiospheres and epicardial cells. We discuss their developmental origins and defining characteristics, and consider their possible contribution to heart organogenesis and regeneration. We also summarize the origin and plasticity of cardiac fibroblasts and circulating endothelial progenitor cells, and consider what role these cells have in contributing to cardiac repair.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0950-1991
1477-9129
DOI:10.1242/dev.111591