The association of melioidosis with climatic factors in Darwin, Australia: A 23-year time-series analysis

• Published in: The Journal of infection Vol. 72; no. 6; pp. 687 - 697
• Main Authors: Kaestli, Mirjam, Grist, Eric P.M, Ward, Linda, Hill, Audrey, Mayo, Mark, Currie, Bart J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2016
• Subjects: Animals; Burkholderia pseudomallei; Burkholderia pseudomallei - isolation & purification; Climate; Cloud cover; Groundwater; Groundwater - microbiology; Humans; Infectious Disease; Melioidosis; Melioidosis - epidemiology; Melioidosis - microbiology; Northern Australia; Northern Territory - epidemiology; Putative incubation period; Rain; Regression Analysis; Sea surface temperature; Seasons; Temperature; Time Factors; Weather; Melioidosis; Weather; Cloud cover; Climate; Groundwater; Sea surface temperature; Putative incubation period; Northern Australia
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1016/j.jinf.2016.02.015

Summary Objectives Melioidosis is an often fatal disease in humans and animals and endemic in Southeast Asia and northern Australia. It is caused by the environmental bacterium Burkholderia pseudomallei . We analysed weather and climate factors preceding new melioidosis cases in Darwin and compared the time between weather event and admission to hospital for severe and average wet season rainfall. Methods In a time-series analysis from 1990 to 2013 we applied a boosted regression tree and a negative binomial model to investigate the association between melioidosis cases and weather events. Fitted Fourier terms controlled for long-term seasonal trends. Results We found a rise in the dew point, cloud cover, rainfall, maximum temperature and groundwater to be associated with an increased risk to acquire melioidosis. A shorter ‘putative’ incubation period was evident after severe rainfall events. Rainfall occurring early in the wet season was linked to more cases as was an increase in the local sea surface temperature reflecting local weather dynamics and precipitation. Conclusions Our findings demonstrate a statistical association between frequency of recorded melioidosis cases and the nature and timing of rainfall related events and suggest a future rise in the sea surface and ambient temperature may lead to increased melioidosis.