Genomic imprinting in development, growth, behavior and stem cells

Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 141; no. 9; pp. 1805 - 1813
Main Authors Plasschaert, Robert N., Bartolomei, Marisa S.
Format Journal Article
LanguageEnglish
Published England The Company of Biologists 01.05.2014
Subjects
Animals
Behavior
Cellular Reprogramming - genetics
Genomic Imprinting
Growth and Development - genetics
Humans
Nervous System - embryology
Reviews
Stem Cells - metabolism
Fetal growth
DNA methylation
Behavior
Imprinted genes
Neuronal development
Induced pluripotency
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Summary:Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal function. Finally, new studies have revealed the importance of proper expression of specific imprinted genes in induced pluripotent stem cells and in adult stem cells. As we review here, these findings highlight the complex nature and developmental importance of imprinted genes.
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Present address: 9-123 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
ISSN:0950-1991
1477-9129
1477-9129
DOI:10.1242/dev.101428