Inherited Primary Hypothyroidism in Mice

• Published in: Science (American Association for the Advancement of Science) Vol. 212; no. 4490; pp. 61 - 63
• Main Authors: Beamer, Wesley G., Eicher, Eva M., Maltais, Lois J., Southard, Janice L.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 03.04.1981; American Association for the Advancement of Science
• Subjects: Alleles; Anemia - etiology; Animals; Cholesterol - blood; Chromosome Mapping; Chromosomes; Congenic strains; Crosses, Genetic; Female; Genes; Genes, Recessive; Hormones; Humans; Hyperthyroidism; Hypothyroidism; Hypothyroidism - blood; Hypothyroidism - genetics; Hypothyroidism - veterinary; Liver; Male; Mating behavior; Mice; Mice, Mutant Strains - genetics; Rodent Diseases - genetics; Thyroid diseases; Thyroid gland; Thyroid Gland - pathology; Thyrotropin - metabolism

A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum...