Inherited Primary Hypothyroidism in Mice

A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 212; no. 4490; pp. 61 - 63
Main Authors Beamer, Wesley G., Eicher, Eva M., Maltais, Lois J., Southard, Janice L.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 03.04.1981
American Association for the Advancement of Science
Subjects
Alleles
Anemia - etiology
Animals
Cholesterol - blood
Chromosome Mapping
Chromosomes
Congenic strains
Crosses, Genetic
Female
Genes
Genes, Recessive
Hormones
Humans
Hyperthyroidism
Hypothyroidism
Hypothyroidism - blood
Hypothyroidism - genetics
Hypothyroidism - veterinary
Liver
Male
Mating behavior
Mice
Mice, Mutant Strains - genetics
Rodent Diseases - genetics
Thyroid diseases
Thyroid gland
Thyroid Gland - pathology
Thyrotropin - metabolism
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Summary:A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.7209519