Inherited Primary Hypothyroidism in Mice
A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum...
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| Published in | Science (American Association for the Advancement of Science) Vol. 212; no. 4490; pp. 61 - 63 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The American Association for the Advancement of Science
03.04.1981
American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone. |
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| AbstractList | A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone. A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid ( hyt ), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone. |
| Audience | Academic |
| Author | Maltais, Lois J. Southard, Janice L. Eicher, Eva M. Beamer, Wesley G. |
| Author_xml | – sequence: 1 givenname: Wesley G. surname: Beamer fullname: Beamer, Wesley G. – sequence: 2 givenname: Eva M. surname: Eicher fullname: Eicher, Eva M. – sequence: 3 givenname: Lois J. surname: Maltais fullname: Maltais, Lois J. – sequence: 4 givenname: Janice L. surname: Southard fullname: Southard, Janice L. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7209519$$D View this record in MEDLINE/PubMed |
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| Snippet | A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on... A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid ( hyt ), has been mapped on... |
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| SubjectTerms | Alleles Anemia - etiology Animals Cholesterol - blood Chromosome Mapping Chromosomes Congenic strains Crosses, Genetic Female Genes Genes, Recessive Hormones Humans Hyperthyroidism Hypothyroidism Hypothyroidism - blood Hypothyroidism - genetics Hypothyroidism - veterinary Liver Male Mating behavior Mice Mice, Mutant Strains - genetics Rodent Diseases - genetics Thyroid diseases Thyroid gland Thyroid Gland - pathology Thyrotropin - metabolism |
| Title | Inherited Primary Hypothyroidism in Mice |
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