Orthotopic liver transplantation for primary sclerosing cholangitis

• Published in: Annals of surgery Vol. 207; no. 1; pp. 21 - 25
• Main Authors: MARSH, J. W. JR, IWATSUKI, S, MAKOWKA, L, ESQUIVEL, C. O, GORDON, R. D, TODO, S, TZAKIS, A, MILLER, C, VAN THIEL, D, STARZL, T. E
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 1988
• Subjects: Adenoma, Bile Duct - surgery; Adolescent; Adult; Biological and medical sciences; Cholangiography; Cholangitis - diagnostic imaging; Cholangitis - mortality; Cholangitis - surgery; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver Neoplasms - surgery; Liver Transplantation; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Recurrence; Sclerosis; Time Factors; Human; Postoperative; Biliary tract; Cholangiography; Radiodiagnosis; Liver; Homotransplantation; Survival; Result; Primitive; Surgery; Digestive diseases; Sclerosing cholangitis
• ISSN: 0003-4932; 1528-1140
• DOI: 10.1097/00000658-198801000-00005

The incidence or diagnostic rate of sclerosing cholangitis is increasing. Because of the lack of effective medical or surgical therapy for patients with end-stage liver disease and sclerosing cholangitis, results with orthotopic liver transplantation were examined. The results of 55 consecutive liver replacements for this disease were reviewed. The 1- and 2-year actuarial survival rates are 71% and 57%, respectively. Orthotopic liver transplantation for end-stage liver disease from sclerosing cholangitis has emerged as the most effective therapy.