Fibromyalgia and the complex regional pain syndrome: similarities in pathophysiology and treatment

Abstract Although the pain of fibromyalgia usually is not preceded by an injury to the involved tissue, whereas that of the complex regional pain syndrome usually starts at a site of prior trauma or surgery, both disorders may share a common mechanism—pathologic sensitization of brain mechanisms tha...

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Bibliographic Details
Published inMetabolism, clinical and experimental Vol. 59; pp. S37 - S40
Main Author Wurtman, Richard J
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2010
Subjects
Complex Regional Pain Syndromes - drug therapy
Complex Regional Pain Syndromes - etiology
Complex Regional Pain Syndromes - physiopathology
Endocrinology & Metabolism
Fibromyalgia - drug therapy
Fibromyalgia - etiology
Fibromyalgia - physiopathology
Humans
Ketamine - therapeutic use
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Summary:Abstract Although the pain of fibromyalgia usually is not preceded by an injury to the involved tissue, whereas that of the complex regional pain syndrome usually starts at a site of prior trauma or surgery, both disorders may share a common mechanism—pathologic sensitization of brain mechanisms that integrate nociceptive signals—and both apparently respond to treatment with ketamine, an anesthetic-analgesic agent whose actions include blockade of N -methyl- d -aspartate receptors. Ketamine's widespread illegal use as a recreational agent probably precludes developing it as a general treatment of centrally mediated pain disorders; however, its efficacy suggests that related, to-be-discovered agents could be useful.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2010.07.008