Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats

Highlights • Chlorogenic acid is a potent antioxidant belonging to phenolic acids which are abundant in the diet. • This compound improved biochemical parameters altered in urine and serum of rats exposed to OTA. • This polyphenol reduced pathological damages in kidneys of rats exposed to OTA. • Chl...

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Published inEnvironmental toxicology and pharmacology Vol. 43; pp. 105 - 111
Main Authors Cariddi, L.N, Escobar, F.M, Sabini, M.C, Campra, N.A, Bagnis, G, Decote-Ricardo, D, Freire-de-Lima, C.G, Mañas, F, Sabini, L.I, Dalcero, A.M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2016
Subjects
Animals
Carcinogens - toxicity
Chlorogenic acid
Emergency
Hydroxybenzoates - pharmacology
Kidney - drug effects
Kidney damage
Male
Ochratoxin A
Ochratoxins - toxicity
Oral treatment
Oxidative stress
Oxidative Stress - drug effects
Protective Agents - pharmacology
Protective effects
Rats
Rats, Wistar
Toxicity Tests, Chronic
ALAT
Oxidative stress
ochratoxin A
Protective effects
ALP
DMSO
dimethylsulfoxide
haematoxylin/eosin
H&E
alanine aminotransferase
thiobarbituric acid reactive substances
SOD
TBARS
Chlorogenic acid
MDA
superoxide dismutase
alkaline phosphatase
Oral treatment
malondialdehyde
Kidney damage
OTA
Ochratoxin A
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Summary:Highlights • Chlorogenic acid is a potent antioxidant belonging to phenolic acids which are abundant in the diet. • This compound improved biochemical parameters altered in urine and serum of rats exposed to OTA. • This polyphenol reduced pathological damages in kidneys of rats exposed to OTA. • Chlorogenic acid showed a good protective activity, but not by an antioxidant mechanism.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.03.004