Acinetobacter calcoaceticus–Acinetobacter baumannii complex species in clinical specimens in Singapore

• Published in: Epidemiology and infection Vol. 140; no. 3; pp. 535 - 538
• Main Authors: KOH, T. H., TAN, T. T., KHOO, C. T., NG, S. Y., TAN, T. Y., HSU, L-Y., OOI, E. E., VAN DER REIJDEN, T. J. K., DIJKSHOORN, L.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2012
• Subjects: Acinetobacter baumannii - drug effects; Acinetobacter baumannii - isolation & purification; Acinetobacter calcoaceticus - drug effects; Acinetobacter calcoaceticus - isolation & purification; Acinetobacter Infections - epidemiology; Acinetobacter Infections - microbiology; Antimicrobial agents; Bacteriology; beta-Lactam Resistance; beta-Lactamases - genetics; Biological and medical sciences; Carbapenems - pharmacology; Cloning; Cluster Analysis; Cross Infection - epidemiology; Cross Infection - microbiology; Drug resistance; Fundamental and applied biological sciences. Psychology; Genes; HAI; Hospitals; Humans; Microbiology; Miscellaneous; Molecular Typing; Prevalence; Singapore - epidemiology; Asia; South east Asia; Singapore; Taiwan; molecular epidemiology; bacterial infections; Antibiotic resistance; hospital microbiology; bacterial typing; Acinetobacter baumannii; Acinetobacter calcoaceticus; Tropical zone; Neisseriaceae; Bacteria; Micrococcales; Species complex; Epidemiology; Clinical isolate
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268811001129

This study was performed to determine the prevalence, distribution of specimen sources, and antimicrobial susceptibility of the Acinetobacter calcoaceticus–Acinetobacter baumannii (Acb) species complex in Singapore. One hundred and ninety-three non-replicate Acb species complex clinical isolates were collected from six hospitals over a 1-month period in 2006. Of these, 152 (78·7%) were identified as A. baumannii, 18 (9·3%) as ‘Acinetobacter pittii’ [genomic species (gen. sp.) 3], and 23 (11·9%) as ‘Acinetobacter nosocomialis’ (gen. sp. 13TU). Carbapenem resistance was highest in A. baumannii (72·4%), followed by A. pittii (38·9%), and A. nosocomialis (34·8%). Most carbapenem-resistant A. baumannii and A. nosocomialis possessed the blaOXA-23-like gene whereas carbapenem-resistant A. pittii possessed the blaOXA-58-like gene. Two imipenem-resistant strains (A. baumannii and A. pittii) had the blaIMP-like gene. Representatives of carbapenem-resistant A. baumannii were related to European clones I and II.