Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients

Abstract An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqu...

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Published inComputer methods and programs in biomedicine Vol. 114; no. 3; pp. e29 - e38
Main Authors Keir, R, Evans, N.D, Hutchison, C.A, Vigano, M.R, Stella, A, Fabbrini, P, Storr, M, Chappell, M.J
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.05.2014
Subjects
Algorithms
Computer Simulation
Dialysis
Humans
Internal Medicine
Kinetics
Models, Theoretical
Myoglobin
Myoglobin - isolation & purification
Other
Parameter estimation
Renal Dialysis - methods
Rhabdomyolysis
Software
Structural identifiability
Myoglobin
Parameter estimation
Dialysis
Structural identifiability
Kinetics
Rhabdomyolysis
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Summary:Abstract An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqueness given certain clinical observations. A Taylor series expansion method was implemented which found that the model was structurally globally/uniquely identifiable for both on- and off-dialysis phases. The fitted model was then used in a predictive capacity showing that the use of Theralite high cut-off (HCO) or HCO 1100 dialyser gave a significant reduction in myoglobin renal exposure compared to standard haemodialysis (HD).
Bibliography:ObjectType-Article-1
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ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2013.07.017