Epidemiology of gastric cancer

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 3; pp. 354 - 362
• Main Authors: Crew, Katherine D, Neugut, Alfred I
• Format: Journal Article
• Language: English
• Published: United States Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, and the Department of Epidemiology,Mailman School of Public Health, Columbia University, New York, NY 10032, United States 21.01.2006; Baishideng Publishing Group Co., Limited
• Subjects: Diet; Helicobacter Infections - complications; Humans; Mass Screening; Review; Risk Factors; Stomach Neoplasms - epidemiology; Stomach Neoplasms - etiology; Stomach Neoplasms - prevention & control; Survival Rate; 临床表现; 流行病学; 病理机制; Epidemiology; Gastric cancer
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i3.354

The incidence and mortality of gastric cancer have fallen dramatically in US and elsewhere over the past several decades. Nonetheless, gastric cancer remains a major public health issue as the fourth most common cancer and the second leading cause of cancer death worldwide. Demographic trends differ by tumor location and histology. While there has been a marked decline in distal, intestinal type gastric cancers, the incidence of proximal, diffuse type adenocarcinomas of the gastric cardia has been increasing, particularly in the Western countries. Incidence by tumor sub-site also varies widely based on geographic location, race, and socioeconomic status. Distal gastric cancer predominates in developing countries, among blacks, and in lower socioeconomic groups, whereas proximal tumors are more common in developed countries, among whites, and in higher socio-economic classes. Diverging trends in the incidence of gastric cancer by tumor location suggest that they may represent two diseases with different etiologies. The main risk factors for distal gastric cancer include Helicobacter pylori （H pylori） infection and dietary factors, whereas gastroesophageal reflux disease and obesity play important roles in the development of proximal stomach cancer. The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention.