The Exocyst at a Glance

The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis...

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Bibliographic Details
Published inJournal of cell science Vol. 128; no. 16; pp. 2957 - 2964
Main Authors Wu, Bin, Guo, Wei
Format Journal Article
LanguageEnglish
Published England The Company of Biologists 15.08.2015
Subjects
Animals
Cell Cycle - genetics
Cell Membrane - genetics
Cell Membrane - metabolism
Cell Science at A Glance
Exocytosis - genetics
Humans
Membrane Fusion - genetics
Membrane Fusion Proteins - genetics
Membrane Fusion Proteins - metabolism
Morphogenesis - genetics
rab GTP-Binding Proteins - genetics
rab GTP-Binding Proteins - metabolism
ral Guanine Nucleotide Exchange Factor - genetics
ral Guanine Nucleotide Exchange Factor - metabolism
Vesicular Transport Proteins - genetics
Vesicular Transport Proteins - metabolism
Rho
Membrane fusion
Rab
Vesicle tether
Ral
Exocyst
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Summary:The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.
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ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.156398