Enantioselective Oxidation of Aldehydes Catalyzed by Alcohol Dehydrogenase

Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofact...

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Published inAngewandte Chemie (International ed.) Vol. 51; no. 39; pp. 9914 - 9917
Main Authors Könst, Paul, Merkens, Hedda, Kara, Selin, Kochius, Svenja, Vogel, Andreas, Zuhse, Ralf, Holtmann, Dirk, Arends, Isabel W. C. E., Hollmann, Frank
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 24.09.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Alcohol dehydrogenase
Alcohol Dehydrogenase - genetics
Alcohol Dehydrogenase - metabolism
alcohol dehydrogenases
alcohol oxidation
Alcohols - metabolism
aldehyde oxidation
Aldehydes
Aldehydes - metabolism
Chemistry
Chemistry, Multidisciplinary
Dogs
dynamic kinetic resolution
Dynamical systems
Dynamics
Education
Escherichia coli - enzymology
Escherichia coli - genetics
Kinetics
Lactobacillus - enzymology
Oxidation-Reduction
Physical Sciences
profens
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Regeneration
Science & Technology
Selectivity
Stereoisomerism
Teaching
aldehyde oxidation
COFACTOR REGENERATION
BIOCATALYTIC OXIDATION
alcohol oxidation
DYNAMIC-KINETIC-RESOLUTION
SECONDARY ALCOHOLS
NADH OXIDASE
DISMUTASE ACTIVITY
SEC-ALCOHOLS
ENZYME
alcohol dehydrogenases
HYDROGEN-TRANSFER
ASYMMETRIC REDUCTION
dynamic kinetic resolution
profens
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Summary:Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.
Bibliography:ArticleID:ANIE201203219
Deutsche Bundesstiftung Umwelt
istex:A3B6367D1535E3352B00B8491B3A5568DF831804
Support by the Deutsche Bundesstiftung Umwelt, ChemBioTec (AZ 13253) is gratefully acknowledged.
ark:/67375/WNG-SJRG59DT-S
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203219