Roles of p38 MAPK signalling in intervertebral disc degeneration

• Published in: Cell proliferation Vol. 56; no. 8; pp. e13438 - n/a
• Main Authors: Shi, Zheng‐wei, Zhu, Lei, Song, Zong‐rang, Liu, Tuan‐jiang, Hao, Ding‐jun
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2023; John Wiley and Sons Inc
• Subjects: Ablation; Antigens; Apoptosis; Autophagy; Cell cycle; Cell division; Cell proliferation; Degeneration; Degenerative diseases; Extracellular matrix; Inflammation; Inflammatory response; Intervertebral discs; Kinases; MAP kinase; Molecular modelling; Oxidative stress; Phosphatase; Phosphorylation; Protein kinase; Proteins; Regulation; Review; Reviews; Senescence; Therapeutic targets; Threonine; Tumor necrosis factor-TNF
• ISSN: 0960-7722; 1365-2184
• DOI: 10.1111/cpr.13438

Intervertebral disc degeneration (IVDD) is a common degenerative disease mediated by multiple factors. Because of its complex aetiology and pathology, no specific molecular mechanisms have yet been identified and no definitive treatments are currently available for IVDD. p38 mitogen‐activated protein kinase (MAPK) signalling, part of the serine and threonine (Ser/Thr) protein kinases family, is associated with the progression of IVDD, by mediating the inflammatory response, increasing extracellular matrix (ECM) degradation, promoting cell apoptosis and senescence and suppressing cell proliferation and autophagy. Meanwhile, the inhibition of p38 MAPK signalling has a significant effect on IVDD treatment. In this review, we first summarize the regulation of p38 MAPK signalling and then highlight the changes in the expression of p38 MAPK signalling and their impact on pathological process of IVDD. Moreover, we discuss the current applications and future prospects of p38 MAPK as a therapeutic target for IVDD treatment. Intervertebral disc degeneration (IVDD) is a common degenerative disease mediated by multiple factors. Because of its complex aetiology and pathology, no specific molecular mechanisms have yet been identified and no definitive treatments are currently available for IVDD. p38 mitogen‐activated protein kinase (MAPK) signalling, part of the serine and threonine (Ser/Thr) protein kinases family, is associated with the progression of IVDD, by mediating the inflammatory response, increasing extracellular matrix (ECM) degradation, promoting cell apoptosis and senescence and suppressing cell proliferation and autophagy. Meanwhile, the inhibition of p38 MAPK signalling has a significant effect on IVDD treatment. In this review, we first summarize the regulation of p38 MAPK signalling and then highlight the changes in the expression of p38 MAPK signalling and their impact on pathological process of IVDD. Moreover, we discuss the current applications and future prospects of p38 MAPK as a therapeutic target for IVDD treatment.