Cachexia as a common characteristic in multiple chronic disease

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 9; no. 7; pp. 1189 - 1191
• Main Authors: Scherbakov, Nadja, Doehner, Wolfram
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc; Wiley
• Subjects: cachexia; Cachexia - diagnosis; Cachexia - etiology; Cachexia - mortality; Cachexia - therapy; cancer; Cancer therapies; chronic diseases; Chronic illnesses; Chronic obstructive pulmonary disease; Humans; Metabolism; Multiple Chronic Conditions; muscle wasting; Musculoskeletal system; NMR; Nuclear magnetic resonance; Sarcopenia; Stroke; Studies; cancer; chronic diseases; muscle wasting; cachexia
• ISSN: 2190-5991; 2190-6009; 2190-6009
• DOI: 10.1002/jcsm.12388

The assessment of longitudinal changes of body composition by computed tomography (CT) revealed three phenotypes of body wasting in these patients: patients who lost skeletal muscle and fat tissue, patients who only lost fat tissue, and patients without wasting who had a significantly improved survival. Importantly, apart from the assessment of muscle bulk, functional and metabolic characteristics of the skeletal muscle tissue might have a role in the determination of functional capacity and symptomatic severity of muscle wasting and hence may have an impact on clinical outcome. Body weight loss after neurological stroke is frequently observed in clinical and experimental settings and associated with adverse clinical outcome.