Development of a New Polypropylene-Based Suture: Plasma Grafting, Surface Treatment, Characterization, and Biocompatibility Studies

• Published in: Macromolecular bioscience Vol. 11; no. 3; pp. 373 - 382
• Main Authors: Saxena, Shalini, Ray, Alok R., Kapil, Arti, Pavon-Djavid, Graciela, Letourneur, Didier, Gupta, Bhuvanesh, Meddahi-Pellé, Anne
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 10.03.2011; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: 3T3 Cells; Animals; Anti-Infective Agents - pharmacology; Applied sciences; Biocompatibility; Biocompatible Materials - chemical synthesis; Biological and medical sciences; Cell Survival - drug effects; Chitosan; Chitosan - chemistry; Cosmetics; Escherichia coli - drug effects; Exact sciences and technology; General pharmacology; Grafting and modifications; Male; Materials Testing - methods; Mechanical Phenomena - drug effects; Medical sciences; Mice; Microbial Sensitivity Tests; Microorganisms; Microscopy, Electron, Scanning; Nanostructure; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Plasma Gases - chemistry; plasma polymerization; Polymerization; Polymers and radiations; polypropylene; Polypropylenes; Polypropylenes - chemical synthesis; Polypropylenes - chemistry; Prosthesis Implantation; Rats; Rats, Wistar; Staphylococcus aureus - drug effects; Surface Properties - drug effects; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; suture; Sutures; Technology. Biomaterials. Equipments; Tetracycline - pharmacology; Biological properties; Plasma; Propylene copolymer; Graft copolymer; Nanoparticle; Synthetic fiber; Immobilization; Cytotoxicity; Drug carrier; Grafting; Intramuscular administration; Biocompatibility; Biomaterial; Nanocomposite; Release; Acrylic acid copolymer; Control release polymer; Propylene polymer; Suturation; Experimental study; Metal particle; In vitro; Tetracycline; Silver; Animal; Morphology; Preparation; Kinetics; Antibacterial agent
• ISSN: 1616-5187; 1616-5195; 1616-5195
• DOI: 10.1002/mabi.201000298

Polypropylene sutures (PP) are already used in surgery. Because microbial infection leads to complications, we developed antimicrobial PP suture by plasma‐induced graft polymerization of acrylic acid followed by chitosan binding on the remaining carboxyl groups. Mechanical properties and surface morphologies were analyzed on these sutures. Tetracycline hydrochloride (TC) or nanosilver (NS) was then immobilized to PP. The resulting PP sutures evidenced drug release properties and antimicrobial activity in vitro. PP implanted in vivo for 30 days in the muscle of rats showed the absence of adverse effects and a tissue organization. This new polypropylene suture with suitable antimicrobial features appears to be a promising macromolecular material for clinical and cosmetic applications. We develop antimicrobial PP sutures by plasma‐induced graft polymerization of acrylic acid followed by chitosan binding on the remaining carboxyl groups. TC or nanosilver (NS) is subsequently immobilized on suture surface. Resulting PP sutures evidence drug release properties and antimicrobial activity in vitro and a tissue organization in vivo. This antimicrobial PP suture appears to be a promising macromolecular material for clinical applications.