Food insecurity is associated with higher respiratory quotient and lower glucagon‐like peptide 1

• Published in: Obesity (Silver Spring, Md.) Vol. 30; no. 6; pp. 1248 - 1256
• Main Authors: Booker, Jetaun M., Chang, Douglas C., Stinson, Emma J., Mitchell, Cassie M., Votruba, Susanne B., Krakoff, Jonathan, Gluck, Marci E., Cabeza de Baca, Tomás
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2022
• Subjects: Adult; Appetite; Biomarkers; Carbohydrates; Cardiovascular disease; Chronic illnesses; Diabetes; Diet; Eating behavior; Endorsements; Energy; Energy Intake - physiology; Energy Metabolism - physiology; Food Insecurity; Food security; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Laboratories; Male; Metabolism; Nervous system; Obesity - metabolism; Oxidation; Peptides; Physiology; Proteins; Thyroid gland; United States > US
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.23437

Objective Food insecurity is known to be associated with obesity, but its association with physiological measures is unclear. Therefore, it was hypothesized that, compared with food‐secure individuals, those with food insecurity would have higher 24‐hour energy expenditure (EE [kilocalories per day]) and 24‐hour respiratory quotient (RQ [ratio]). Subsequently, hormones involved in appetite regulation, substrate oxidation, and EE were explored. Methods A total of 113 healthy participants without diabetes (75 men; mean [SD], age 40 [12] years; BMI 30 [8] kg/m2) were included in this analysis. Participants completed the Food Security Short Form, underwent a dual‐energy x‐ray absorptiometry scan, and spent 24 hours in a human respiratory chamber following a weight‐maintaining diet. Results Compared with individuals with food security, participants with food insecurity had no difference in 24‐hour EE. However, they had higher carbohydrate oxidation rates (p = 0.03) and lower lipid oxidation rates (p = 0.02), resulting in higher 24‐hour RQ (p < 0.01). They also had lower fasting glucagon‐like peptide 1 (p = 0.03) concentrations. Conclusions Food insecurity is associated with higher 24‐hour RQ and lower fasting glucagon‐like peptide 1 concentrations, metabolic and hormonal differences previously shown to drive greater calorie intake in the setting of unrestricted food availability. These findings therefore provide new insight into the paradoxical link between restricted food access and increased adiposity.