Functional hierarchy of the angular gyrus and its underlying genetic architecture

• Published in: Human brain mapping Vol. 44; no. 7; pp. 2815 - 2828
• Main Authors: Song, Yu, Wang, Chunli, Cai, Huanhuan, Chen, Jingyao, Liu, Siyu, Zhu, Jiajia, Yu, Yongqiang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2023
• Subjects: Adults; angular gyrus; Annotations; Association analysis; Brain; Brain architecture; Brain Mapping; Cerebrum; Cognition; Consortia; Contraindications; Correlation analysis; Datasets; functional gradient; Functional magnetic resonance imaging; Functional morphology; functional MRI; Functionally gradient materials; Gene expression; Geometry; Head injuries; Heterogeneous structure; hierarchical organization; Humans; Image processing; Magnetic Resonance Imaging; Medical imaging; Neural networks; Neuroimaging; Parietal Lobe - anatomy & histology; Pregnancy; Scanners; Sensorimotor system; Subdivisions; Visual perception; functional MRI; functional gradient; hierarchical organization; angular gyrus; gene expression
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.26247

The angular gyrus (AG), given its rich connectivity and its location where multisensory information converges, is a functionally and anatomically heterogeneous structure. Using the state‐of‐the‐art functional gradient approach and transcription‐neuroimaging association analysis, we sought to determine whether there is an overarching hierarchical organization of the AG and if so, how it is modulated by the underlying genetic architecture. Resting‐state functional MRI data of 793 healthy subjects were obtained from discovery and validation datasets. Functional gradients of the AG were calculated based on the voxel‐wise AG‐to‐cerebrum functional connectivity patterns. Combined with the Allen Human Brain Atlas, we examined the spatial correlations between the AG functional gradient and gene expression. The dominant gradient topography showed a dorsoanterior–ventroposterior hierarchical organization of the AG, which was related to its intrinsic geometry. Concurrently, AG functional subdivisions corresponding to canonical functional networks (behavioral domains) were distributed along the dominant gradient in a hierarchical manner, that is, from the default mode network ( cognition) at one extreme to the visual and sensorimotor networks (perception and action) at the other extreme. Remarkably, we established a link between the AG dominant gradient and gene expression, with two gene sets strongly contributing to this link but diverging on their functional annotation and specific expression. Our findings represent a significant conceptual advance in AG functional organization, and may introduce novel approaches and testable questions to the investigation of AG function and anatomy in health and disease. We comprehensively characterized the overarching hierarchical organization of the angular gyrus and its underlying genetic architecture by applying a combined approach of the functional gradient and transcription‐neuroimaging association to large‐scale discovery and validation rs‐fMRI datasets.