Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch

• Published in: Journal of the science of food and agriculture Vol. 104; no. 3; pp. 1382 - 1390
• Main Authors: Gözcü, Sefa, Akşit, Zeynep, Şimşek, Samed, Kandemir, Ali, Aydın, Ali, Yılmaz, Mustafa Abdullah, Akşit, Hüseyin
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2024; John Wiley and Sons, Limited
• Subjects: 2,2-diphenyl-1-picrylhydrazyl; agriculture; Anti-Bacterial Agents - pharmacology; antibacterial; Antibacterial activity; antibacterial properties; antioxidant; antioxidant activity; Antioxidants; Antioxidants - chemistry; antiproliferative; Antiproliferatives; Apiaceae; Bacillus cereus; Bioactive compounds; Biological activity; biological assessment; Biological effects; Chlorogenic acid; Chlorogenic Acid - pharmacology; Cytotoxicity; E coli; Escherichia coli; Ferulago setifolia K. Koch; Formulations; Glucosides; Industrial applications; Kaempferol; LC–MS/MS; Liquid chromatography; Mass spectrometry; Mass spectroscopy; methanol; Phenolic compounds; Phenols; Phenols - analysis; Phytochemicals; Phytochemicals - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Pseudomonas aeruginosa; Quercetin; Quinic acid; Scavenging; Staphylococcus aureus; tandem mass spectrometry; LC-MS/MS; antioxidant; Ferulago setifolia K. Koch; antibacterial; antiproliferative
• ISSN: 0022-5142; 1097-0010; 1097-0010
• DOI: 10.1002/jsfa.13017

BACKGROUND Ferulago setifolia K. Koch (Apiaceae) has been the subject of this study, aiming to comprehensively determine its phenolic fingerprint and evaluate its various biological activities. The liquid chromatography–tandem mass spectrometry analysis of the 70% methanol extract of F. setifolia (FS) revealed the presence of 23 phytochemicals, among which chlorogenic acid, quinic acid, kaempferol‐3‐O‐glucoside, and quercetin‐3‐O‐glucoside were identified as the major phenolics in the extract. RESULTS The biological screening included examinations of antioxidant, antibacterial, antiproliferative, and cytotoxic activities. The FS extract displayed moderate 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging and ferric‐reducing capacity, indicating moderate antioxidant activity. Furthermore, FS exhibited significant antiproliferative effects on cancer cells while showing low cytotoxicity on normal cells. The antibacterial activity findings revealed that FS demonstrated potent activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. CONCLUSION The findings of this study suggest that the methanolic extract of FS holds promise as a potential source of biologically active compounds. It can be utilized for the development of pharmaceutical formulations, thanks to its significant antiproliferative and antibacterial activities. Additionally, FS can serve as a valuable source of chlorogenic acid for industrial applications. © 2023 Society of Chemical Industry.