Continuous Stochastic Detection of Amino Acid Enantiomers with a Protein Nanopore

A stochastic sensing method: Discrimination between enantiomeric amino acids is achieved when the amino acids bind to a CuII complex within a protein nanopore sensor, which provides a chiral environment. The potential of the method is demonstrated by real‐time observation of the increase in enantiom...

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Published inAngewandte Chemie International Edition Vol. 51; no. 38; pp. 9606 - 9609
Main Authors Boersma, Arnold J., Bayley, Hagan
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 17.09.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Amino acids
Amino Acids - chemistry
biosensors
chirality
copper
Detection
Discrimination
Enantiomers
membrane proteins
Molecular Structure
Nanopores
Nanostructure
Phenanthrolines - chemistry
Proteins
Proteins - chemistry
Real time
Sensors
Stereoisomerism
Stochastic Processes
Stochasticity
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Summary:A stochastic sensing method: Discrimination between enantiomeric amino acids is achieved when the amino acids bind to a CuII complex within a protein nanopore sensor, which provides a chiral environment. The potential of the method is demonstrated by real‐time observation of the increase in enantiomeric excess during an enzymatic kinetic resolution.
Bibliography:Netherlands Organization for Scientific Research
Medical Research Council
ArticleID:ANIE201205687
istex:EE60BBDBED317450C961DA660FF627F040C91CEC
Oxford Nanopore Technologies
ark:/67375/WNG-89PLDW47-C
This work was supported by the Netherlands Organization for Scientific Research (NWO, Rubicon Fellowship, A.J.B.), the Medical Research Council, and Oxford Nanopore Technologies.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201205687