Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches

• Published in: Annals of the New York Academy of Sciences Vol. 1066; no. 1; pp. 136 - 151
• Main Authors: FRIDLYAND, LEONID E., PHILIPSON, LOUIS H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2006
• Subjects: Animals; Antioxidants - metabolism; Antioxidants - therapeutic use; beta-cell; Cells - metabolism; Cells - pathology; Diabetes Complications; diabetes mellitus; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - therapy; Humans; insulin resistance; Insulin Resistance - physiology; Insulin-Secreting Cells - metabolism; mitochondria; Oxidative Stress; Reactive Oxygen Species - metabolism
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1196/annals.1363.019

: Mammalian cells are continuously subject to insult from reactive species. Most of the pathogenic mechanisms that have been considered to date reflect overproduction of reactive oxygen species (ROS) or a peculiar failure in intracellular defenses against ROS. We have attempted to consider briefly the most important mechanisms of ROS production, defense, and reactive species‐induced cell damage and approaches to therapy, focusing on the example of diabetes mellitus. An improved understanding of these mechanisms should facilitate development of antioxidant intervention strategies leading to reduction in diseases associated with oxidative stress.