Two New Avermectin Derivatives from the Beibu Gulf Gorgonian Anthogorgia caerulea

• Published in: Chemistry & biodiversity Vol. 11; no. 5; pp. 812 - 818
• Main Authors: Gao, Chenghai, Wang, Yibing, Chen, Yinning, He, Bijuan, Zhang, Rongcan, Xu, Mingben, Huang, Riming
• Format: Journal Article
• Language: English
• Published: Zürich WILEY-VCH Verlag 01.05.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Animals; Anthogorgia caerulea; Anthozoa - chemistry; Antifouling activity; Avermectins B1c and B1e; Balanus amphitrite; Biofouling - prevention & control; Disinfectants - chemistry; Disinfectants - isolation & purification; Disinfectants - metabolism; Gorgonacea; Ivermectin - analogs & derivatives; Ivermectin - chemistry; Ivermectin - isolation & purification; Ivermectin - metabolism; Larva - drug effects; Larva - growth & development; Thoracica - drug effects; Thoracica - growth & development; Avermectins B1c and B1e; Antifouling activity; Anthogorgia caerulea
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.201300265

Two new avermectin derivatives, avermectins B1c and B1e (1 and 2, resp.), as well as two known compounds, avermectin B2a (3) and ivermectin A1a (4), were isolated from a Beibu Gulf gorgonian coral, Anthogorgia caerulea. The structures of the new compounds were established by detailed spectroscopic analysis and by comparison with spectral data of related known compounds. Compounds 1–4 showed moderate antifouling activities against the larval settlement of Balanus amphitrite.