Major mixed motility disorders: An important subset of esophagogastric junction outflow obstruction

• Published in: Neurogastroenterology and motility Vol. 35; no. 7; pp. e14555 - n/a
• Main Authors: Leopold, Andrew R., Jalalian, Aria, Thaker, Parth, Wellington, Jennifer, Papademetriou, Marianna, Xie, Guofeng
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2023
• Subjects: Benchmarking; Coexistence; Contractility; distal esophageal spasm; endoscopic functional lumen imaging probe; Esophageal diseases; Esophageal Motility Disorders; Esophagogastric Junction; esophagogastric junction outflow obstruction; Esophagus; high‐resolution manometry; Humans; hypercontractile esophagus; jackhammer esophagus; lower esophageal sphincter; Manometry; Motility; Muscle Contraction; Peristalsis; Stomach Diseases; endoscopic functional lumen imaging probe; esophagogastric junction outflow obstruction; lower esophageal sphincter; jackhammer esophagus; distal esophageal spasm; esophageal motility disorders; high-resolution manometry; hypercontractile esophagus
• ISSN: 1350-1925; 1365-2982; 1365-2982
• DOI: 10.1111/nmo.14555

Background Esophagogastric junction outflow obstruction (EGJOO) is an esophageal motility disorder characterized by a lack of relaxation of the esophagogastric junction (EGJ), with preserved esophageal body peristalsis. We propose new terminology for the coexistence of EGJOO with hypercontractile esophagus and distal esophageal spasm as a major mixed motility disorder (MMMD), and normal peristalsis or a minor disorder of peristalsis such as ineffective esophageal motility with EGJOO as isolated or ineffective EGJOO (IEGJOO). Methods We reviewed prior diagnoses of EGJOO, stratified diagnoses as IEGJOO or MMMD, and compared their symptomatic presentations, high‐resolution manometry (HRM) and endoluminal functional lumen imaging probe (EndoFLIP) metrics, and treatment responses at 2–6 months of follow‐up. Results Out of a total of 821 patients, 142 met CCv3 criteria for EGJOO. Twenty‐two were confirmed by CCv4 and EndoFLIP as having EGJOO and were clinically managed. Thirteen had MMMD, and nine had IEGJOO. Groups had no difference in demographic data or presenting symptoms by Eckardt score (ES). HRM showed MMMD had greater distal contractile integral, frequency of hypercontractile swallows, and frequency of spastic swallows, and greater DI by EndoFLIP. Patients with MMMD showed greater reduction in symptoms after LES‐directed intervention when measured by ES compared with IEGJOO (7.2 vs. 4.0). Conclusion Patients with MMMD and IEGJOO present similarly. Detectable differences in HRM portend different responses to endoscopic therapy. Because patients with MMMD have greater short‐term prognosis, they should be considered a different diagnostic classification to guide therapy. We compared therapeutic responses to two different subsets of EGJOO: major mixed motility disorder (MMMD) and isolated or ineffective EGJOO (IEGJOO) and found that patients with MMMD have greater short‐term prognosis and should be considered a different diagnostic classification.