Microbial Transformation of 14-Anhydrodigoxigenin by Alternaria alternata

The microbial transformation of 14‐anhydrodigoxigenin (1) by Alternaria alternata CGMCC 3.577 led to the production of seven new metabolites, 2–8. Their structures were determined by extensive spectroscopic (CD, IR, 1D‐ and 2D‐NMR, and HR‐ESI‐MS) data analyses. The reactions in the bioprocess exhibi...

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Published inChemistry & biodiversity Vol. 12; no. 12; pp. 1871 - 1880
Main Authors Liu, Jimei, Tang, Wanxia, Chen, Ridao, Dai, Jungui
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.12.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
14-Anhydrodigoxigenin
Activation, Metabolic
Alternaria - chemistry
Alternaria - metabolism
Alternaria alternata
Cardenolides
Digoxigenin - analogs & derivatives
Digoxigenin - chemistry
Hydroxylation
Magnetic Resonance Spectroscopy
Microbial transformation
Molecular Structure
14-Anhydrodigoxigenin
Cardenolides
Alternaria alternata
Microbial transformation
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Summary:The microbial transformation of 14‐anhydrodigoxigenin (1) by Alternaria alternata CGMCC 3.577 led to the production of seven new metabolites, 2–8. Their structures were determined by extensive spectroscopic (CD, IR, 1D‐ and 2D‐NMR, and HR‐ESI‐MS) data analyses. The reactions in the bioprocess exhibited diversity, including specific oxidation, hydroxylation, reduction, epoxidation, and dehydration. In addition, a hypothetical biocatalytic pathway is proposed.
Bibliography:ark:/67375/WNG-TVCK39HZ-0
ArticleID:CBDV201500024
istex:E031035E203FEAE1B8BC21CA21B4BCA652376B9C
These authors contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201500024