Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia

• Published in: Circulation. Arrhythmia and electrophysiology Vol. 14; no. 8; p. e009887
• Main Authors: Leblanc, Francis J.A., Hassani, Faezeh Vahdati, Liesinger, Laura, Qi, Xiaoyan, Naud, Patrice, Birner-Gruenberger, Ruth, Lettre, Guillaume, Nattel, Stanley
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.08.2021
• Subjects: Animals; Atrial Fibrillation - genetics; Atrial Fibrillation - physiopathology; Calcium-Binding Proteins - biosynthesis; Calcium-Binding Proteins - genetics; Disease Models, Animal; Dogs; Electrocardiography; Female; Follow-Up Studies; Gene Expression Regulation; Heart Atria - physiopathology; Male; Membrane Proteins - biosynthesis; Membrane Proteins - genetics; MicroRNAs - genetics; Original; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; Time Factors; Transcriptome - genetics; microRNAs; transcriptomics; atrial remodeling; atrial fibrillation; glutamate
• ISSN: 1941-3084; 1941-3149; 1941-3084
• DOI: 10.1161/CIRCEP.121.009887

Supplemental Digital Content is available in the text. Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with increased morbidity, mortality, and health care costs. AF develops over many years and is often related to substantial atrial structural and electrophysiological remodeling. AF may lack symptoms at onset, and atrial biopsy samples are generally obtained in subjects with advanced disease, so it is difficult to study earlier stage pathophysiology in humans.