Biosynthesis and Mass Spectrometric Imaging of Tolaasin, the Virulence Factor of Brown Blotch Mushroom Disease

Killing them softly. The molecular basis for the biosynthesis of tolaasin, the Pseudomonas tolaasii‐derived causative agent of mushroom (Agaricus bisporus) soft rot, was revealed by genome mining and analysis of the NRPS genes. Production of the toxic lipopeptides during infection was confirmed by i...

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 14; no. 18; pp. 2439 - 2443
Main Authors Scherlach, Kirstin, Lackner, Gerald, Graupner, Katharina, Pidot, Sacha, Bretschneider, Tom, Hertweck, Christian
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.12.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Agaricus - physiology
Agaricus bisporus
Amino Acid Sequence
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
biosynthesis
Depsipeptides - analysis
Depsipeptides - genetics
Depsipeptides - metabolism
Genome, Bacterial
MALDI imaging
mass spectrometry
Molecular Sequence Data
Multigene Family
NRPS
Pseudomonas
Pseudomonas - genetics
Pseudomonas - metabolism
Pseudomonas costantinii
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Virulence Factors - analysis
Virulence Factors - genetics
Virulence Factors - metabolism
Agaricus bisporus
mass spectrometry
NRPS
Pseudomonas costantinii
biosynthesis
MALDI imaging
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Summary:Killing them softly. The molecular basis for the biosynthesis of tolaasin, the Pseudomonas tolaasii‐derived causative agent of mushroom (Agaricus bisporus) soft rot, was revealed by genome mining and analysis of the NRPS genes. Production of the toxic lipopeptides during infection was confirmed by imaging mass spectrometry.
Bibliography:ArticleID:CBIC201300553
ark:/67375/WNG-DTXHP16M-F
International Leibniz Research School (ILRS)
Jena School for Microbial Communication (JSMC)
istex:2654CA40E1631D8727C86D246B4CCEAFBD879CF5
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201300553