Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies

Correlated light and electron microscopic study of four fibrous histiocytomas of proven malignancy has confirmed the presence of histiocyte‐like and fibroblast‐like cells in this tumor. In addition, an undifferentiated cell type, giant cells, xanthomatous cells, and rare cells with morphological cha...

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Bibliographic Details
Published inCancer Vol. 35; no. 1; pp. 176 - 198
Main Authors Fu, Yao‐Shi, Gabbiani, Giulio, Kaye, Gordon I., Lattes, Raffaele
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.01.1975
Subjects
Adult
Aged
Cell Nucleus - ultrastructure
Culture Techniques
Cytoplasm - ultrastructure
Female
Fibroblasts - pathology
Hand - pathology
Histiocytes - pathology
Histiocytoma, Benign Fibrous - pathology
Humans
Intercellular Junctions - ultrastructure
Male
Microscopy, Electron
Middle Aged
Thigh - pathology
Thoracic Neoplasms - pathology
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Summary:Correlated light and electron microscopic study of four fibrous histiocytomas of proven malignancy has confirmed the presence of histiocyte‐like and fibroblast‐like cells in this tumor. In addition, an undifferentiated cell type, giant cells, xanthomatous cells, and rare cells with morphological characteristics intermediate between those of histiocytes and fibroblasts were seen. “Nuclear body” type inclusions were commonly present in both principal cell types in all four cases, as were the somewhat less common cytoplasmic inclusion bodies. Electron microscopic study of a tissue culture of one of these tumors demonstrated only fibroblast‐like, histiocyte‐like, and xanthomatous cells. The possibility is suggested that both principal cell types in this tumor may derive from the same undifferentiated stem cell.
Bibliography:Professor of Pathology, the Department de Pathologie, Faculté de Medicine, Université de Genève, Genève, Switzerland.
Associate Professor of Surgical Pathology; recipient of Research Career Development Award KO‐4‐AM‐70333 from the NIAMDD, NIH, USPHS.
Chief Resident Surgical Pathology. Current position: Assistant Professor of Surgical Pathology, Medical College of Virginia, Richmond, VA.
Professor of Surgical Pathology.
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197501)35:1<176::AID-CNCR2820350123>3.0.CO;2-N