Lipid droplet dynamics in alcoholic fatty liver disease

The rising incidence of alcohol-related liver disease (ALD) demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular damage. One of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets (LDs) in the hepa...

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Bibliographic Details
Published inLiver research Vol. 3; no. 3-4; pp. 185 - 190
Main Authors Schulze, Ryan J., Ding, Wen-Xing
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.12.2019
KeAi Communications Co., Ltd
Subjects
Alcohol
Autophagy
Hepatocyte
Lipid droplet (LD)
Lipolysis
Steatosis
Lipid droplet (LD)
Alcohol
Hepatocyte
Autophagy
Lipolysis
Steatosis
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Summary:The rising incidence of alcohol-related liver disease (ALD) demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular damage. One of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets (LDs) in the hepatocellular cytoplasm. LDs are far from inert sites of neutral lipid storage; rather, they represent key organelles that play vital roles in the metabolic state of the cell. In this review, we will examine the biology of these structures and outline recent efforts being made to understand the effects of alcohol exposure on the biogenesis, catabolism, and motility of LDs and how their dynamic nature is perturbed in the context of ALD.
Bibliography:Both authors wrote, critically reviewed, and edited the manuscript.
Authors’ contributions
ISSN:2542-5684
2096-2878
2542-5684
DOI:10.1016/j.livres.2019.09.002