Nonblinking Plasmonic Quantum Dot Assemblies for Multiplex Biological Detection

Nonblinking nanosystems are prepared by layer‐by‐layer polyelectrolyte deposition, which precisely controls the stoichiometry and the distance between quantum dots (QDs) and gold nanoparticles (GNPs). Conjugation of biorecognition molecules to these nanobarcodes enables cell targeting and entry with...

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Published inAngewandte Chemie (International ed.) Vol. 51; no. 35; pp. 8773 - 8777
Main Authors Song, Fayi, Tang, Peter S., Durst, Holly, Cramb, David T., Chan, Warren C. W.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 27.08.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Acrylates - chemistry
cellular uptake
Conjugation
Deposition
Electrolytes - chemistry
fluorescence detection
Gold - chemistry
gold nanoparticles
Metal Nanoparticles - chemistry
Microscopy, Fluorescence
Multiplexing
nanobarcodes
Nanoparticles
Nanostructure
Plasmonics
Polyelectrolytes
Polystyrenes - chemistry
Quantum Dots
Stoichiometry
Toxicity
Ultraviolet Rays
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Summary:Nonblinking nanosystems are prepared by layer‐by‐layer polyelectrolyte deposition, which precisely controls the stoichiometry and the distance between quantum dots (QDs) and gold nanoparticles (GNPs). Conjugation of biorecognition molecules to these nanobarcodes enables cell targeting and entry with prolonged retention and minimal toxicity.
Bibliography:W.C. and D.C. acknowledges the Canadian Institute of Health Research (MOP-93532; G118160781), Natural Sciences and Engineering Research Council of Canada (NETGP 35015-07, RGPIN 288231-09, and 203312-08), Canadian Research Chairs Program (950-203403), Canadian Foundation for Innovation, and Ontario Ministry of Research and Innovation for funding support. P. T. would like to acknowledge the Queen Elizabeth II Graduate Scholarships in Science and Technology (Canada) and the International Graduate Scholarships (Taiwan).
Natural Sciences and Engineering Research Council of Canada - No. NETGP 35015-07; No. RGPIN 288231-09; No. 203312-08
Canadian Research Chairs Program - No. 950-203403
ArticleID:ANIE201201872
Ontario Ministry of Research and Innovation
ark:/67375/WNG-H6DGD34N-9
Canadian Foundation for Innovation
istex:5AD299897CA2F5E6A07E070FE7795A858E5A7F0C
Canadian Institute of Health Research - No. MOP-93532; No. G118160781
W.C. and D.C. acknowledges the Canadian Institute of Health Research (MOP‐93532; G118160781), Natural Sciences and Engineering Research Council of Canada (NETGP 35015‐07, RGPIN 288231‐09, and 203312‐08), Canadian Research Chairs Program (950‐203403), Canadian Foundation for Innovation, and Ontario Ministry of Research and Innovation for funding support. P. T. would like to acknowledge the Queen Elizabeth II Graduate Scholarships in Science and Technology (Canada) and the International Graduate Scholarships (Taiwan).
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201201872