Epicardial adipose tissue thickness is associated with reduced peak oxygen consumption and systolic reserve in patients with type 2 diabetes and normal heart function

• Published in: Diabetes, obesity & metabolism Vol. 25; no. 1; pp. 177 - 188
• Main Authors: Nesti, Lorenzo, Pugliese, Nicola Riccardo, Chiriacò, Martina, Trico, Domenico, Baldi, Simona, Natali, Andrea
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2023; Wiley Subscription Services, Inc
• Subjects: Adipose tissue; Adipose Tissue - diagnostic imaging; Anaerobic threshold; Body fat; cardiopulmonary exercise test; cardiopulmonary fitness; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; diabetic cardiomyopathy; Echocardiography; effort intolerance; epicardial adipose tissue; Exercise; heart failure with preserved ejection fraction; Heart rate; Humans; Natriuretic Peptides; Original; Oxygen; Oxygen Consumption; Peptides; Respiratory function; type 2 diabetes; Ventricle; effort intolerance; heart failure with preserved ejection fraction; type 2 diabetes; echocardiography; epicardial adipose tissue; cardiopulmonary exercise test; diabetic cardiomyopathy; cardiopulmonary fitness
• ISSN: 1462-8902; 1463-1326; 1463-1326
• DOI: 10.1111/dom.14861

Aim To investigate the impact of epicardial adipose tissue (EAT) thickness on cardiopulmonary performance in patients with type 2 diabetes (T2D) and normal heart function. Materials and methods We analysed EAT thickness in subjects with T2D and normal biventricular systo‐diastolic functions undergoing a maximal cardiopulmonary exercise test combined with stress echocardiography, speckle tracking and pulmonary function assessment, as well as serum N‐terminal pro B‐type natriuretic peptide (NT‐proBNP). Results In the 72 subjects enrolled, those with EAT thickness above the median (> 5 mm) showed higher body fat mass, smaller indexed left ventricular dimensions and marginally reduced diastolic function variables at rest. Higher EAT thickness was associated with lower peak oxygen uptake (VO2peak 17.1 ± 3.6 vs. 21.0 ± 5.7 ml/min/kg, P = .001), reduced systolic reserve (ΔS′ 4.6 ± 1.6 vs. 5.8 ± 2.5 m/s, P = .02) and higher natriuretic peptides (NT‐proBNP 64 [29‐165] vs. 31 [26‐139] pg/ml, P = .04), as well as chronotropic insufficiency and impaired heart rate recovery. Ventilatory variables and peripheral oxygen extraction were not different between groups. EAT was independently associated with VO2peak and linearly and negatively correlated with peak heart rate, heart rate recovery, workload, VO2 at the anaerobic threshold and at peak, and cardiac power output, and was directly correlated with natriuretic peptides. Conclusion Higher EAT thickness in T2D is associated with worse cardiopulmonary performance and multiple traits of subclinical cardiac systolic dysfunction.