General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review
The Notch signalling pathway appears to be ubiquitous in virtually all cell‐cell contacts in all metazoan animals, and is best known and most throughout studied in Drosophila melanogaster. In this species the Notch signalling pathway regulates, with both positive and negative signals, the differenti...
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Published in | Hereditas Vol. 136; no. 2; pp. 89 - 96 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Copenhagen
Munksgaard International Publishers
01.06.2002
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Subjects | |
Online Access | Get full text |
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Summary: | The Notch signalling pathway appears to be ubiquitous in virtually all cell‐cell contacts in all metazoan animals, and is best known and most throughout studied in Drosophila melanogaster. In this species the Notch signalling pathway regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disc, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. In general, the pathway works as follows: Notch is most likely a dimeric transmembrane receptor at the cell surface, where it is activated by its ligands Serrate and/or Delta from the neighbouring cell Fringe, discriminating between the two ligands. Then, the receptor is cleaved by a proteolytic mechanism in which Presenilin plays an important role, and the intracellular domain is transferred to the nucleus, where it, together with the Suppressor of Hairless protein, constitutes a transcription factor which activates the Notch target genes, mainly located in the Enhancer of split complex. These target genes then encode repressor proteins. |
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Bibliography: | istex:42C190D19825A26E5E3234932EFCE9F28379254D ark:/67375/WNG-S9QPKBS1-R ArticleID:HRD21360201 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0018-0661 1601-5223 |
DOI: | 10.1034/j.1601-5223.2002.1360201.x |