Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified t...
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Published in | Bioengineering & translational medicine Vol. 4; no. 1; pp. 83 - 95 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.01.2019
John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified to simulate the mechanical and biochemical properties of the cell microenvironment, they do not mimic in full the multitude of interactions that take place within tissue. Decellularized extracellular matrix (dECM) has been established as a biomaterial that preserves a tissue's native environment, promotes cell proliferation, and provides cues for cell differentiation. The potential of dECM as a therapeutic agent is rising, but there are many limitations of dECM restricting its use. This review discusses the recent progress in the utilization of bone and cartilage dECM through applications as scaffolds, particles, and supplementary factors in bone and cartilage tissue engineering.
This review looks at the leading applications of decellularized extracellular matrix for bone and cartilage tissue repair. The advantages and disadvantage of dECM as scaffolds, particles, bioinks, and cell‐laid ECM in regeneration of injured bone and cartilage tissue are discussed, along with a look to improving the utilization of dECM and the field of bone and tissue engineering. |
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Bibliography: | Funding information National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: R01 AR068073; National Institute of Biomedical Imaging and Bioengineering, Grant/Award Number: P41 EB023833 ; National Science Foundation, Grant/Award Number: Graduate Research Fellowship Program; National Institutes of Health, Grant/Award Numbers: AR068073, R01, EB023833, P41 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this study. Manuscript submitted for consideration and publication in the Bioengineering & Translational Medicine special issue in honor of Professors Robert Langer and Nicholas Peppas. Funding information National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: R01 AR068073; National Institute of Biomedical Imaging and Bioengineering, Grant/Award Number: P41 EB023833 ; National Science Foundation, Grant/Award Number: Graduate Research Fellowship Program; National Institutes of Health, Grant/Award Numbers: AR068073, R01, EB023833, P41 |
ISSN: | 2380-6761 2380-6761 |
DOI: | 10.1002/btm2.10110 |