Applications of decellularized extracellular matrix in bone and cartilage tissue engineering

Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified t...

Full description

Saved in:
Bibliographic Details
Published inBioengineering & translational medicine Vol. 4; no. 1; pp. 83 - 95
Main Authors Kim, Yu Seon, Majid, Marjan, Melchiorri, Anthony J., Mikos, Antonios G.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.01.2019
John Wiley and Sons Inc
Subjects
bioink
Biological activity
Biomedical materials
bone
Bones
Cartilage
Cell growth
Chemical compounds
Collagen
decellularization
Differentiation (biology)
Extracellular matrix
Growth factors
hydrogels
Methods
particles
Pharmacology
Review
Reviews
scaffold
Tissue engineering
decellularization
scaffold
cartilage
bioink
bone
hydrogels
particles
extracellular matrix
Online AccessGet full text

Cover

More Information
Summary:Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified to simulate the mechanical and biochemical properties of the cell microenvironment, they do not mimic in full the multitude of interactions that take place within tissue. Decellularized extracellular matrix (dECM) has been established as a biomaterial that preserves a tissue's native environment, promotes cell proliferation, and provides cues for cell differentiation. The potential of dECM as a therapeutic agent is rising, but there are many limitations of dECM restricting its use. This review discusses the recent progress in the utilization of bone and cartilage dECM through applications as scaffolds, particles, and supplementary factors in bone and cartilage tissue engineering. This review looks at the leading applications of decellularized extracellular matrix for bone and cartilage tissue repair. The advantages and disadvantage of dECM as scaffolds, particles, bioinks, and cell‐laid ECM in regeneration of injured bone and cartilage tissue are discussed, along with a look to improving the utilization of dECM and the field of bone and tissue engineering.
Bibliography:Funding information
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: R01 AR068073; National Institute of Biomedical Imaging and Bioengineering, Grant/Award Number: P41 EB023833 ; National Science Foundation, Grant/Award Number: Graduate Research Fellowship Program; National Institutes of Health, Grant/Award Numbers: AR068073, R01, EB023833, P41
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this study.
Manuscript submitted for consideration and publication in the Bioengineering & Translational Medicine special issue in honor of Professors Robert Langer and Nicholas Peppas.
Funding information National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: R01 AR068073; National Institute of Biomedical Imaging and Bioengineering, Grant/Award Number: P41 EB023833 ; National Science Foundation, Grant/Award Number: Graduate Research Fellowship Program; National Institutes of Health, Grant/Award Numbers: AR068073, R01, EB023833, P41
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10110