Phenol esters and other constituents from the stem barks of Stereospermum acuminatissimum

• Published in: Journal of asian natural products research Vol. 13; no. 12; pp. 1128 - 1134
• Main Authors: Sob, Sylvain Valère Tanemossu, Wabo, Hippolyte Kamdem, Tang, Chun-Ping, Tane, Pierre, Ngadjui, Bonaventure Tchaleu, Ye, Yang
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis Group 01.12.2011; Taylor & Francis; Taylor & Francis Ltd
• Subjects: anthraquinones; Anthraquinones - chemistry; antifungal activity; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Bacteria; Bignoniaceae; Bignoniaceae - chemistry; Biological and medical sciences; Cameroon; Candida albicans; Candida albicans - drug effects; Candida glabrata; Candida glabrata - drug effects; Candida krusei; Candida parapsilosis; Chemistry; Chemistry, Applied; Chemistry, Medicinal; Esters; Fatty Acids - chemistry; Fatty Acids - isolation & purification; Fatty Acids - pharmacology; General pharmacology; Iridoids - chemistry; Iridoids - isolation & purification; Life Sciences & Biomedicine; lignans; Lignans - chemistry; Lignans - isolation & purification; Medical sciences; metabolites; Microbial Sensitivity Tests; Microbiology; Molecular Structure; nuclear magnetic resonance spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; phenol; phenol esters; Phenols - chemistry; Phenols - isolation & purification; Phenols - pharmacology; phenylpropanoids; Phenylpropionates - chemistry; Phenylpropionates - isolation & purification; Physical Sciences; Plant Bark - chemistry; Plant Sciences; Science & Technology; spectral analysis; Stereospermum; Stereospermum acuminatissimum; Triterpenes - chemistry; Triterpenes - isolation & purification; triterpenoids; Cameroon; Africa; PERSONATUM; ANTHRAQUINONES; LEAVES; Bignoniaceae; antifungal activity; Stereospermum acuminatissimum; phenol esters; Aliphatic compound; Pharmacognosy; Bark; Biological activity; Stem; Medicinal plant; Ester; Antifungal agent; Folk medicine; Dicotyledones; Cinnamic acid derivatives; Angiospermae; Plant origin; Phenols; Isolation; Spermatophyta; Structural analysis
• ISSN: 1477-2213; 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2011.619182

A new ester, 2-(4′-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3 phenylpropanoids, 2 4-hydroxyphenethyl esters, 1 methoxyphenol, and 1 iridoid. The structures of the new metabolites were determined with the help of spectroscopic data including extensive 2D NMR spectroscopy. The known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. The compounds were tested against Candida albicans ATCC 24433, C. albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Candida parapsilosis ATCC 22019. Some of them were moderately active.