Cytoprotective effect of piperine against benzo[ a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice

• Published in: Fitoterapia Vol. 74; no. 1; pp. 109 - 115
• Main Authors: Selvendiran, K, Singh, J.Prince Vijeya, Krishnan, K.Baba, Sakthisekaran, D
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.2003; Elsevier
• Subjects: Administration, Oral; Alkaloids; Animals; Antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Benzo(a)pyrene; Benzodioxoles; Biological and medical sciences; Cytoprotection; General pharmacology; Lipid Peroxidation - drug effects; Lung - drug effects; Lung - enzymology; Lung - metabolism; Lung cancer; Lung Neoplasms - chemically induced; Lung Neoplasms - prevention & control; Male; Medical sciences; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Piperidines - administration & dosage; Piperidines - pharmacology; Piperidines - therapeutic use; Piperine; Polyunsaturated Alkamides; Antioxidants; Benzo[ a]pyrene; Piperine; Lung cancer; Antineoplastic agent; Lipids; Bronchopulmonary; Medicinal plant; Prevention; Dicotyledones; Angiospermae; Bronchus disease; Benzo[a]pyrene; Phytotherapy; Mechanism of action; Peroxidation; Lung disease; Respiratory disease; Rodentia; Piperaceae; Malignant tumor; Antioxidant; Carcinogen; Vertebrata; Mammalia; Mouse; Animal; Plant origin; Spermatophyta; Piper
• ISSN: 0367-326X
• DOI: 10.1016/S0367-326X(02)00304-0

The cytoprotective effect of piperine on benzo[ a]pyrene (B[ a]P) induced experimental lung cancer was investigated in male Swiss albino mice. Oral administration of piperine (100 mg/kg body wt.) effectively suppressed lung cancer initiated with B[ a]P as revealed by the decrease in the extent of lipid peroxidation with concomitant increase in the activities of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymatic antioxidant (reduced glutathione, vitamin E and vitamin C) levels when compared to lung cancer bearing animals. Our data suggest that piperine may extend its chemopreventive effect by modulating lipid peroxidation and augmenting antioxidant defense system.