Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

• Published in: Medicina (Kaunas, Lithuania) Vol. 57; no. 11; p. 1280
• Main Authors: Jo, Yumin, Kim, Yeojung, Park, Eunhye, Lee, Yuran, Kim, Jiyeon, Kang, Minwoong, Lim, Jaesung, Song, Insang, Lim, Chaeseong, Jeon, Byeonghwa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.11.2021; MDPI
• Subjects: Anesthesia; APEX1 protein; cancer; Cancer surgery; Catheters; Consciousness; Consent; Correlation analysis; DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism; Endonucleases; Humans; Medical personnel; Medical prognosis; Neoplasm Staging; Neoplasms - surgery; Observational studies; Oxidation-Reduction; Patients; Plasma; Prognosis; propofol; surgery; United States > US; cancer; propofol; APEX1 protein; anesthesia; surgery
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina57111280

: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics target plasma apurinic apyrimidinic endonuclease/redox effector factor-1 (APE1/Ref-1) as a possible mechanism of action. : The plasma APE1/Ref-1 level was evaluated three times during surgery for cancer, i.e., before anesthesia, immediately after cancer resection, and finally, in the recovery room. Blood (3 cc) was drawn from the radial artery catheter, and plasma APE1/Ref-1 levels were compared according to measurement time and between the two groups. Spearman's Rho correlation analysis was performed to determine relationships among body mass index, American Society of Anesthesiologists classification, age, sex, cancer type, and tumor-node-metastasis (TNM) stage. A total of 166 patients (VIA: 129; TIVA: 37) were enrolled. : Plasma APE1/Ref-1 level increased significantly ( = 0.028) after cancer resection compared with before surgery, but no significant difference was observed between anesthetics ( = 0.134). The post-resection plasma APE1/Ref-1 level showed a positive correlation with the NM stages, but not the T stage. : The plasma APE1/Ref-1 level increased during surgery with more severe lymph node invasion, but there were no significant differences according to the anesthetics used.