Heatstroke-induced acute kidney injury and the innate immune system

Heatstroke can cause multiple organ failure and systemic inflammatory response syndrome as the body temperature rises beyond the body’s ability to regulate temperature in a hot environment. Previous studies have indicated that heatstroke-induced acute kidney injury (AKI) can lead to chronic kidney d...

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Published inFrontiers in medicine Vol. 10; p. 1250457
Main Authors Goto, Hiroyasu, Kinoshita, Manabu, Oshima, Naoki
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 08.08.2023
Subjects
heat-related illness (HRI)
macrophage
mast cell (MC)
Medicine
neutrophil
NK cells
NKT (natural killer T) cells
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Summary:Heatstroke can cause multiple organ failure and systemic inflammatory response syndrome as the body temperature rises beyond the body’s ability to regulate temperature in a hot environment. Previous studies have indicated that heatstroke-induced acute kidney injury (AKI) can lead to chronic kidney disease. Therefore, there is an urgent need to elucidate the mechanism of heatstroke-induced AKI and to establish methods for its prevention and treatment. Recent reports have revealed that innate immunity, including neutrophils, macrophages, lymphocytes, and mast cells, is deeply involved in heat-induced AKI. In this review, we will discuss the roles of each immune cell in heat-induced renal injury and their potential therapeutic use.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Takashi Oda, Tokyo Medical University Hachioji Medical Center, Japan
Reviewed by: Eiji Kawamoto, Mie University Hospital, Japan
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2023.1250457