Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 37; pp. 13530 - 13537
• Main Author: Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 07.10.2014
• Subjects: Adolescent; Adult; Aged; Anti-HIV Agents - therapeutic use; Biomarkers - blood; Chi-Square Distribution; Coinfection; DNA, Viral - blood; Drug Therapy, Combination; Female; Hepatitis; Hepatitis B - blood; Hepatitis B - diagnosis; Hepatitis B - epidemiology; Hepatitis B Antibodies - blood; Hepatitis B Surface Antigens - blood; Hepatitis B virus - drug effects; Hepatitis B virus - genetics; Hepatitis B virus - immunology; HIV Infections - diagnosis; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - pathogenicity; Humans; infecti; Male; Mexico - epidemiology; Middle Aged; Molecular Diagnostic Techniques; Occult; Odds Ratio; Predictive Value of Tests; Prevalence; Real-Time Polymerase Chain Reaction; Research Report; Risk Factors; RNA, Viral - blood; Viral Load; virus; Young Adult; Mexico; Molecular diagnostics; Occult hepatitis B virus infection; Hepatitis B virus; Human immunodeficiency virus; Hepatitis B surface antigen negative; Risk factors
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v20.i37.13530

AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson’s χ2 and/or Fisher’s exact test.RESULTS: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV.