Irritable bowel syndrome symptom severity improves equally with probiotic and placebo
AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or p...
Saved in:
Published in | World journal of gastroenterology : WJG Vol. 22; no. 48; pp. 10631 - 10642 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
28.12.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score(IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related QoL questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk runin period, after 4 and 12 wk of intervention, and after a 4-wk washout.RESULTS A total of 340 of 391 randomized volunteers completed the trial. IBS-SSS improved over 12 wk of treatment in all treatment groups, decreasing by a mean ± SD of 44.0 ± 80.2, 50.8 ± 82.4, and 48.3 ± 72.2 in the placebo, active low-dose, and active high-dose groups, respectively. Similarly, secondary outcomes did not differ between treatment groups. However, in a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline(VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively(P value for placebo vs combined active doses = 0.0460).CONCLUSION NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 Author contributions: Lyra A, Hillilä M, Huttunen T, Männikkö S, Taalikka M, Tennilä J, Tarpila A, Lahtinen S, Ouwehand AC and Veijola L designed the study; Veijola L was the principal investigator and Hillilä M was the co-investigator; Lyra A and Ouwehand AC managed the trial; Huttunen T and Männikkö S were responsible for the statistics; Taalikka M performed the data management; Tennilä J and Tarpila A monitored the trial; Lyra A, Hillilä M, Huttunen T, Männikkö S, Taalikka M, Tennilä J, Ouwehand AC, and Veijola L wrote the manuscript; all authors have read and approved the manuscript. Correspondence to: Anna Lyra, PhD, Senior Scientist, DuPont Nutrition and Health, Global Health and Nutrition Science, Danisco Sweeteners Oy, Sokeritehtaantie 20, 02460 Kantvik, Finland. anna.lyra@dupont.com Telephone: +358-40-8241732 Fax: +358-10-4315555 |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v22.i48.10631 |