Silole nanocrystals as novel biolabels

A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph 2Si(CPh) 4; HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL...

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Published in	Journal of immunological methods Vol. 295; no. 1; pp. 111 - 118
Main Authors	Pui-yee Chan, Cangel, Haeussler, Matthias, Zhong Tang, Ben, Dong, Yongqiang, Sin, King-keung, Mak, Wing-cheung, Trau, Dieter, Seydack, Matthias, Renneberg, Reinhard
Format	Journal Article
Language	English
Published	Amsterdam Elsevier B.V 01.12.2004 Elsevier
Subjects	Aggregation-induced emission (AIE) Biolabel Biological and medical sciences Crystallization Fluorescence immunoassay (FIA) Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoassay - methods Layer-by-layer (LbL) technique Molecular immunology Nanotechnology Pilot Projects Silole Spectrophotometry Techniques PBS FDA Layer-by-layer (LbL) technique SDS HPC-SL Ph 2Si(CPh) 4; HPS Biolabel LED Silole BSA PSS FITC THF PAH Aggregation-induced emission (AIE) LbL Gt α M IgG M IgG SEM AIE F/P ratio Fluorescence immunoassay (FIA) FIA Aggregation Immunological method
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Abstract	A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph 2Si(CPh) 4; HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL) technique that provided an “interface” for the attachment of antibodies. A high ratio of fluorescent dyes to biomolecules (F/P ratio; 2.4×10 3) was achieved without self-quenching problem. The aggregation-induced emission (AIE) feature offered silole biolabels the sensitivity 40- to 140-fold higher than that of a start-of-the-art immunoassay using directly fluorescent-labeled antibodies.
AbstractList	A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph2Si(CPh)4HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL) technique that provided an "interface" for the attachment of antibodies. A high ratio of fluorescent dyes to biomolecules (F/P ratio; 2.4 x 10(3)) was achieved without self-quenching problem. The aggregation-induced emission (AIE) feature offered silole biolabels the sensitivity 40- to 140-fold higher than that of a start-of-the-art immunoassay using directly fluorescent-labeled antibodies. A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph sub(2)Si(CPh) sub(4); HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL) technique that provided an ''interface'' for the attachment of antibodies. A high ratio of fluorescent dyes to biomolecules (F/P ratio; 2.4x10 super(3)) was achieved without self-quenching problem. The aggregation-induced emission (AIE) feature offered silole biolabels the sensitivity 40- to 140-fold higher than that of a start-of-the-art immunoassay using directly fluorescent-labeled antibodies. A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were constructed by encapsulating nanocrystalline hexaphenylsilole [Ph 2Si(CPh) 4; HPS] within ultrathin polyelectrolyte layers via the layer-by-layer (LbL) technique that provided an “interface” for the attachment of antibodies. A high ratio of fluorescent dyes to biomolecules (F/P ratio; 2.4×10 3) was achieved without self-quenching problem. The aggregation-induced emission (AIE) feature offered silole biolabels the sensitivity 40- to 140-fold higher than that of a start-of-the-art immunoassay using directly fluorescent-labeled antibodies.
Author	Pui-yee Chan, Cangel Renneberg, Reinhard Dong, Yongqiang Sin, King-keung Seydack, Matthias Haeussler, Matthias Zhong Tang, Ben Mak, Wing-cheung Trau, Dieter
Author_xml	– sequence: 1 givenname: Cangel surname: Pui-yee Chan fullname: Pui-yee Chan, Cangel organization: Department of Chemistry, Biosensors and Bioelectronics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 2 givenname: Matthias surname: Haeussler fullname: Haeussler, Matthias organization: Department of Chemistry, Institute of Nano Materials and Technology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 3 givenname: Ben surname: Zhong Tang fullname: Zhong Tang, Ben organization: Department of Chemistry, Institute of Nano Materials and Technology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 4 givenname: Yongqiang surname: Dong fullname: Dong, Yongqiang organization: Department of Chemistry, Institute of Nano Materials and Technology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 5 givenname: King-keung surname: Sin fullname: Sin, King-keung organization: Department of Chemistry, Biosensors and Bioelectronics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 6 givenname: Wing-cheung surname: Mak fullname: Mak, Wing-cheung organization: Bioengineering Graduate Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China – sequence: 7 givenname: Dieter surname: Trau fullname: Trau, Dieter organization: Division of Bioengineering and Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore – sequence: 8 givenname: Matthias surname: Seydack fullname: Seydack, Matthias organization: 8sens.biognostic AG, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany – sequence: 9 givenname: Reinhard surname: Renneberg fullname: Renneberg, Reinhard email: chrenneb@ust.hk organization: Department of Chemistry, Biosensors and Bioelectronics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
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Keywords	PBS FDA Layer-by-layer (LbL) technique SDS HPC-SL Ph 2Si(CPh) 4; HPS Biolabel LED Silole BSA PSS FITC THF PAH Aggregation-induced emission (AIE) LbL Gt α M IgG M IgG SEM AIE F/P ratio Fluorescence immunoassay (FIA) FIA Aggregation Immunological method
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Snippet	A novel class of biofunctional silole nanocrystals with the potential to create highly sensitive immunoassay was firstly demonstrated. Biolabels were...
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SubjectTerms	Aggregation-induced emission (AIE) Biolabel Biological and medical sciences Crystallization Fluorescence immunoassay (FIA) Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoassay - methods Layer-by-layer (LbL) technique Molecular immunology Nanotechnology Pilot Projects Silole Spectrophotometry Techniques
Title	Silole nanocrystals as novel biolabels
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