Cardiac sympathetic-vagal activity initiates a functional brain–body response to emotional arousal

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 21; pp. 1 - 12
• Main Authors: Candia-Rivera, Diego, Catrambone, Vincenzo, Thayer, Julian F., Gentili, Claudio, Valenza, Gaetano
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.05.2022
• Subjects: Arousal; Arousal - physiology; Autonomic nervous system; Biological Sciences; Brain; Brain - physiology; Cardiovascular system; Computational neuroscience; EEG; EKG; Electrocardiography; Electroencephalography; Emotional factors; Emotions; Emotions - physiology; Heart - innervation; Heart Rate - physiology; Humans; Information transfer; Nervous system; Psychophysiology; Sensory neurons; Social Sciences; Vagus nerve; Vagus Nerve - physiology; causal theory; heart-rate variability; emotion; EEG; brain–heart interplay
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.2119599119

A century-long debate on bodily states and emotions persists. While the involvement of bodily activity in emotion physiology is widely recognized, the specificity and causal role of such activity related to brain dynamics has not yet been demonstrated. We hypothesize that the peripheral neural control on cardiovascular activity prompts and sustains brain dynamics during an emotional experience, so these afferent inputs are processed by the brain by triggering a concurrent efferent information transfer to the body. To this end, we investigated the functional brain–heart interplay under emotion elicitation in publicly available data from 62 healthy subjects using a computational model based on synthetic data generation of electroencephalography and electrocardiography signals. Our findings show that sympathovagal activity plays a leading and causal role in initiating the emotional response, in which ascending modulations from vagal activity precede neural dynamics and correlate to the reported level of arousal. The subsequent dynamic interplay observed between the central and autonomic nervous systems sustains the processing of emotional arousal. These findings should be particularly revealing for the psychophysiology and neuroscience of emotions.